By The AI Sports Dad
Ready for another wild NFL weekend? Here’s your AI-powered, parent-friendly guide to NFL Week 6 predictions, crunching the latest stats, injuries, and more so you can win the family group chat or sound clever at the pub.
Game Previews & AI Picks
Philadelphia Eagles @ New York Giants
Prediction: Eagles 27 – 17 Giants
Win Confidence: 80%
The Eagles look to rebound after a shock loss. Jalen Hurts leads a high-powered offense, and Saquon Barkley is ready to face his old team. With rookie Jaxson Dart starting for the Giants, expect Philly to soar.
Denver Broncos @ New York Jets (in London!)
Prediction: Broncos 24 – 16 Jets
Win Confidence: 75%
Denver’s defense (21 sacks!) and Bo Nix’s steady hand should keep the Jets winless, unless London jetlag strikes.
Arizona Cardinals @ Indianapolis Colts
Prediction: Colts 30 – 20 Cardinals
Win Confidence: 70%
Colts’ offense is rolling, while the Cardinals struggle with injuries and a three-game skid. Indy’s balance should see them through.
Los Angeles Chargers @ Miami Dolphins
Prediction: Chargers 27 – 20 Dolphins
Win Confidence: 70%
Chargers top the AFC West; Dolphins are banged up and missing Tyreek Hill. Justin Herbert could have a field day.
New England Patriots @ New Orleans Saints
Prediction: Patriots 23 – 17 Saints
Win Confidence: 60%
A tight one—Patriots edge it if they avoid turnovers, but the Superdome is never easy.
Cleveland Browns @ Pittsburgh Steelers
Prediction: Steelers 20 – 13 Browns
Win Confidence: 70%
Classic AFC North battle. Steelers’ defense and stability should be the difference.
Dallas Cowboys @ Carolina Panthers
Prediction: Cowboys 28 – 21 Panthers
Win Confidence: 65%
Dallas’ defense, led by Micah Parsons, is likely to be the difference, but the Panthers have momentum.
Seattle Seahawks @ Jacksonville Jaguars
Prediction: Jaguars 23 – 21 Seahawks
Win Confidence: 55%
A toss-up; could go either way with weather and late-game drama.
Los Angeles Rams @ Baltimore Ravens
Prediction: Rams 27 – 16 Ravens
Win Confidence: 85%
No Lamar Jackson means the Rams are clear favourites.
Tennessee Titans @ Las Vegas Raiders
Prediction: Titans 21 – 17 Raiders
Win Confidence: 55%
Cheeky upset alert: Titans’ rookie QB Cam Ward could spark a win in Vegas.
Cincinnati Bengals @ Green Bay Packers
Prediction: Packers 28 – 13 Bengals
Win Confidence: 90%
No Burrow, no hope for the Bengals. Green Bay should cruise.
San Francisco 49ers @ Tampa Bay Buccaneers
Prediction: Buccaneers 24 – 20 49ers
Win Confidence: 65%
Baker Mayfield is on fire; Bucs have the edge at home.
Detroit Lions @ Kansas City Chiefs
Prediction: Lions 30 – 27 Chiefs
Win Confidence: 55%
Game of the week! Lions are hot, but never count out Mahomes.
Buffalo Bills @ Atlanta Falcons
Prediction: Bills 27 – 19 Falcons
Win Confidence: 75%
Bills bounce back, but Falcons’ run game could keep it close.
Chicago Bears @ Washington Commanders
Prediction: Commanders 24 – 20 Bears
Win Confidence: 60%
Rookie QB battle—Commanders’ defense and depth give them the edge.
Quick Picks Table
| Game | Prediction | Win Confidence |
|---|---|---|
| Eagles @ Giants | Eagles 27–17 | 80% |
| Broncos @ Jets | Broncos 24–16 | 75% |
| Colts @ Cardinals | Colts 30–20 | 70% |
| Chargers @ Dolphins | Chargers 27–20 | 70% |
| Patriots @ Saints | Patriots 23–17 | 60% |
| Steelers @ Browns | Steelers 20–13 | 70% |
| Cowboys @ Panthers | Cowboys 28–21 | 65% |
| Seahawks @ Jaguars | Jaguars 23–21 | 55% |
| Rams @ Ravens | Rams 27–16 | 85% |
| Titans @ Raiders | Titans 21–17 | 55% |
| Bengals @ Packers | Packers 28–13 | 90% |
| 49ers @ Buccaneers | Buccaneers 24–20 | 65% |
| Lions @ Chiefs | Lions 30–27 | 55% |
| Bills @ Falcons | Bills 27–19 | 75% |
| Bears @ Commanders | Commanders 24–20 | 60% |
Copy table
Final Whistle
That’s your NFL Week 6 predictions—AI-powered, parent-friendly, and jargon-free. Want more AI sports chat, practical parenting hacks, or a bit of 90s nostalgia? Subscribe to The AI Sports Dad newsletter, explore our AI Sports Prophet hub, and join the conversation!
Sources
All stats, injury updates, and analysis are based on the latest reporting from Fox News, CBS Sports, ESPN, and more. For full links and references, check the original doc or drop us a message.
Linked Sources The Prediction Model References
NFL Week 6 2025 schedule: Eagles-Giants rivalry kicks things off, Bills also in action | Fox News
https://www.foxnews.com/sports/nfl-week-6-schedule-what-know-about-upcoming-games
Saquon Barkley injury: Eagles RB (knee) says he has ‘general soreness,’ is ‘excited’ to play Giants on ‘TNF’ – CBS Sports
NFL Week 6 2025 schedule: Eagles-Giants rivalry kicks things off, Bills also in action | Fox News
https://www.foxnews.com/sports/nfl-week-6-schedule-what-know-about-upcoming-games
Saquon Barkley injury: Eagles RB (knee) says he has ‘general soreness,’ is ‘excited’ to play Giants on ‘TNF’ – CBS Sports
Broncos will try to keep rolling when they face the 0-5 Jets in London – WTOP News
Surprising Colts hope to keep rolling as reeling Cardinals try to snap …
Colts 40-6 Raiders (Oct 5, 2025) Game Recap – ESPN
https://www.espn.com/nfl/recap/_/gameId/401772851
Surprising Colts hope to keep rolling as reeling Cardinals try to snap …
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins face uphill battle as injuries pile up ahead of Week 6 | The Phinsider
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Dolphins and Chargers will try to bounce back from disappointing losses when they meet this week – ABC30 Fresno
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Zac Taylor names the Bengals’ Week 6 starting quarterback | Acme Packing Company
Zac Taylor names the Bengals’ Week 6 starting quarterback | Acme Packing Company
Saquon Barkley injury: Eagles RB (knee) says he has ‘general soreness,’ is ‘excited’ to play Giants on ‘TNF’ – CBS Sports
Broncos will try to keep rolling when they face the 0-5 Jets in London – WTOP News
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Lamar Jackson remains out of practice on Thursday with hamstring …
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall
Joe Burrow Injury Timeline: How Long Joe Flacco Needs to Hold …
https://www.si.com/nfl/joe-burrow-injury-timeline-how-long-joe-flacco-needs-hold-bengals-over
Bengals make important QB decision ahead of Packers game
https://www.newsweek.com/sports/bengals-make-important-qb-decision-ahead-of-packers-game-10848941
Zac Taylor names the Bengals’ Week 6 starting quarterback | Acme Packing Company
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
Buccaneers Quarterback Not Worried About Narrative, Just How He …
Baker Mayfield Named a FedEx Air and Ground Player of the Week
https://www.buccaneers.com/news/baker-mayfield-named-fedex-air-and-ground-player-of-week
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
NFL Week 6 2025 schedule: Eagles-Giants rivalry kicks things off, Bills also in action | Fox News
https://www.foxnews.com/sports/nfl-week-6-schedule-what-know-about-upcoming-games
NFL Week 6 2025 schedule: Eagles-Giants rivalry kicks things off, Bills also in action | Fox News
https://www.foxnews.com/sports/nfl-week-6-schedule-what-know-about-upcoming-games
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall/
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall/
Upset alert in Week 6? Why these five NFL favorites could fall, including Trevor Lawrence and the Jaguars – CBS Sports
https://www.cbssports.com/nfl/news/upset-alert-in-week-6-why-these-five-nfl-favorites-could-fall/
NFL injury updates, Week 6: Ravens’ Lamar Jackson, Cardinals’ Kyler Murray, 49ers’ Brock Purdy miss practice – CBS Sports
NFL Week 6 2025 schedule: Eagles-Giants rivalry kicks things off, Bills also in action | Fox News
https://www.foxnews.com/sports/nfl-week-6-schedule-what-know-about-upcoming-games
Caleb Williams 2025 Stats per Game – NFL – ESPN
https://www.espn.com/nfl/player/gamelog/_/id/4431611/caleb-williams
NFL Schedule – Week 6 Regular Season, 2025 – ESPN
https://www.espn.com/nfl/schedule/_/week/6/year/2025/seasontype/2